Circadian disruption: What do we actually mean?

But What Do We Actually Know?

Knowledge bases such as Wikidata, DBpedia, YAGO, or the Google Knowledge Vault collect a vast number of facts about the world. But while quite some facts are known about the world, little is known about how much is unknown. For example, while the knowledge base may tell us that Barack Obama is the father of Malia Obama and Sasha Obama, it does not tell us whether these are all of his children. ...

Superior Capsule Reconstruction: What Do We Know?

The management of irreparable rotator cuff tears remains challenging. Since its introduction by Mihata in 2012, superiorcapsule reconstruction (SCR) has grown in popularity at an astonishingly rapid rate. The aim of this article is to providea comprehensive review of the available literature, in order to highlight what has so far been published on SCR,covering all aspects including biomechanica...

Redefining MTBDRplus test results: what do indeterminate results actually mean?

BACKGROUND Although line-probe assays (LPAs) are promising, little research has been conducted to elucidate the true nature of indeterminate LPA results or assess the ability of these assays to perform on a wide range of clinical samples. OBJECTIVE To evaluate the performance of the commercially available GenoType(®) MTBDRplus LPA against conventional BACTEC™ MGIT™ 960 culture and drug suscep...

Is fever good? What do we actually know?

In patients with acquired brain injury there is a widely held belief that fever is harmful. However, a critical examination of the literature suggests that these beliefs may be based more on faith and less on science. Cooling the injured brain to prevent further injury makes intuitive sense and is supported by a diverse array of animal studies. However, to date, data from good quality randomise...

What do we actually know about the referral process?